The preparation algorithm and rules are widely presented in available sources. Let's focus on choosing a product most suitable for purification of the object under study. Most often, it is Fortrans (France) which is included in the mandatory “Clinical guidelines”. Its analogues – Lavacol and Moviprep – belong to the same class of laxatives. The main active ingredient of these preparations is macrogol, or polyethylene glycol (PEG), a non-absorbable osmotically acting laxative. What does this mean? Each macrogol molecule binds several water molecules, thereby increasing the fullness of the intestine and causing the urge to empty it. Leaving aside pallatability of these products (each consumer has individual taste preferences), let us focus on the characteristics of solutions containing macrogol and other osmotically active components (for example, sorbitol, mannitol) that are important from the point of view of the methodology and outcomes of using these drugs.

• A long and complex preparatory process (numerous dietary exclusions and limitations);
• Radically increased water intake (not everyone likes it, and some people have contraindications);
• Risk of prolonged effect of unexpected bowel movement;
• Macrogol "collects" all the water in the intestine, and if the volume is not enough, it attracts it from the blood, causing blood thickening, an increase in its viscosity and deterioration of circulation in the bloodstream, which is fraught with clinically significant disorders (pressure drop, heart attack, stroke).
• Because of alkaline composition, Fortrans has an adverse effect on the structure of the gut microbiome.

In cases of incomplete bowel emptying, cloudy “puddles” are formed in it hampering the quality of examination.

The above drawbacks are not observed, if you prepare for a colonoscopy using Matkevich Lavage solution. Experiments and subsequent long-term practical use have shown that this solution cleanses the intestines on a high quality level. In fact, the validity of this statement can be confirmed by anyone who performed a Matkevich Lavage procedure until the rinsing water was clean as indicated in the instructions. The solution contains only natural substances that are part of the human body. Matkevich Lavage causes diarrhea (with a volume over 1-1.5 liters), but is not a laxative. The cleansing effect is only partially due to the action of the solution. Diarrhea is caused by the patient's own bile acids, the secretion of which is stimulated by the solution. The slightly acidic nature (pH 5.5) of the solution promotes the growth of beneficial flora. Moreover, simultaneously with cleansing the intestines, part of the solution is absorbed, and, as a result, the composition and quality of blood improve.



The Matkevich lavage procedure should be performed 5-6 hours after eating or in the morning on an empty stomach. It must be taken into account, that it can last from 1.5 to 4 hours, depending on the individual characteristics of the person. Therefore, it is preferable to perform Matkevich lavage a day before, and the second time – in the morning of the colonoscopy. Such tactics yields the best results of preparation.

05.03.2024
(c) V.A. Matkevich